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There was a small clinical trial (50 participants) for topical viagra for hair loss We confirmed high expression of PDE5 in hDPCs and hHFs. Sildenafil enhances proliferation of hDPCs and up-regulates the mRNA expression of vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF), which are responsible for hair growth.

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Novel effect of sildenafil on hair growth | Request PDF - ResearchGate

Hair growth is also resultant from the follicular keratinocyte proliferating growth factor IGF-I, as well as other PRP growth factors including FGF and PDGF (26,29). ... (Viagra), and more ...

Novel effect of sildenafil on hair growth

However, the effect of sildenafil on human hair follicles (hHFs) is unknown.OBJECTIVE: The purpose of this study was to determine the role of sildenafil in hair growth.METHODS: We investigated the expression of PDE5 in human dermal papilla cells (hDPCs) and hHFs. The effects of sildenafil on hDPC proliferation were evaluated using BrdU assays.