Effect of Sildenafil Citrate on Intraocular Pressure and Blood Pressure ...

Based on these observations, we found it remarkable that a study of the potential effects of sildenafil on the IOP of patients with primary open angle glaucoma (POAG) reported no effects of the drug on either IOP or systemic blood pressure (Grunwald et al., 2001a). Because this was an early report following the marketing of Viagra by Pfizer, we ...

Effect of periodic sildenafil dosage on intraocular pressure in ...

The side-effects of sildenafil on the smooth muscles of the eye include changes in blood flow, retinal function and retinal pigment epithelium as well as the impairment of IOP and glaucoma . The cGMP and smooth muscles play a role in the production and drainage of the aqueous humor that determines IOP (10, 11).

Acute effects of sldenafil ctrate (Viagra) on intraocular pressure in ...

Purpose: To assess the acute effects of sildenafil citrate (VIAGRA) on the intraocular pressure (IOP) of patients with chronic open-angle glaucoma. Design: This was a double-blind, randomized, placebo-controlled, crossover study, in which 15 patients received a single oral dose of sildenafil 100 mg or matching placebo on two separate occasions.

Regular Use of Erectile Dysfunction Drugs Associated With Eye Problems

Regular use of phosphodiesterase type 5 inhibitors (PDE5Is) for erectile dysfunction was associated with increased risks of serous retinal detachment (SRD), retinal vascular occlusion (RVO), and ischemic optic neuropathy (ION) among older US men in a large observational study.PDE5Is are among the most prescribed medication classes in the US and include avanafil (Stendra), sildenafil (Viagra ...

Sildenafil in ophthalmology: An update - PubMed

Sildenafil citrate, a selective oral phosphodiesterase 5 inhibitor, is a widely used drug for erectile dysfunction that acts by elevating cGMP levels and causing smooth muscle relaxation. It also has 10% activity against PDE6, a key enzyme in phototransduction cascade in the retina. Recent ocular im …

Monitor recipients of phosphodiesterase type 5 inhibitors for glaucoma ...

Glaucoma is a leading cause of bilateral blindness. Phosphodiesterase type 5 inhibitors (PDE5Is; e.g. avanafil, sildenafil, tadalafil and vardenafil) may increase blood flow to the ciliary body, thereby elevating intraocular pressure and increasing the risk of glaucoma. PDE5Is are commonly used to treat erectile dysfunction, as well as benign prostatic hyperplasia (tadalafil) and pulmonary ...