Sildenafil-associated Nonarteritic Anterior Ischemic Optic Neuropathy

Sildenafil-associated Nonarteritic Anterior Ischemic Optic Neuropathy Howard D. Pomeranz, MD, PhD,1 Kyle H. Smith, MD,2 William M. Hart, Jr., MD, PhD,3 Robert A. Egan, MD4 Purpose: To describe the clinical features of five patients who developed nonarteritic anterior ischemic optic neuropathy (NAION) after ingestion of sildenafil citrate (Viagra; Pfizer Pharmaceuticals, New York, NY).

Erectile dysfunction drugs and risk of anterior ischaemic optic ...

NAION is a sudden irreversible cause of visual loss with a poorly understood aetiology that affects up to 10 adults per 100 000 each year. Following a series of such case reports, WHO and FDA have labelled the association between use of PDE5 inhibitors and risk of NAION as "possibly" causal. ... Three PDE5 inhibitors—sildenafil (Viagra ...

Sildenafil-Induced Nonarteritic Anterior Ischemic Optic Neur ...

To date there are 4 reported cases of patients developing NAION when on Sildenafil for pulmonary hypertension. The first was a 6-year-old girl who underwent surgical repair of coarctation of the aorta at age 2 years and mitral valve replacement with pacemaker insertion at age 4 years. She presented with a several month history of monocular ...