Migraine can be induced by sildenafil without changes in middle ...

We examined whether sildenafil (Viagra ®), a selective inhibitor of cGMP‐hydrolysing phosphodiesterase 5 (PDE5), which acts exclusively by increasing cGMP, can induce migraine and dilatation of cerebral arteries. We included 12 patients with migraine without aura in this double‐blind, placebo‐controlled crossover study, in which placebo ...

The headache and aura-inducing effects of sildenafil in ... - PubMed

Methods: In a randomized, double-blinded, placebo-controlled crossover study, 16 patients with migraine with aura (of whom 11 patients exclusively had attacks of migraine with aura) received 100 mg sildenafil or placebo on two separate days. The development, duration, and characteristics of aura and headache were recorded using a questionnaire.

The headache and aura-inducing effects of sildenafil in patients with ...

During the past three decades, human migraine models have been developed to elucidate the initiating mechanisms of migraine. Studies of experimental migraine induction have revealed important signaling pathways involved in the initiation of migraine headache, including those mediated by the second messenger molecules cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate ...

Migraine Is Associated With High Risk of Erectile Dysfunction: A ...

Migraine-induced ED may be correlated with multiple factors, that is, chronic illnesses, chronic pain, and psychosocial causes (like anxiety and depression). Since phosphodiesterase-5 inhibitors (ie, sildenafil) might induce or exacerbate migraine, thus it is not recommended to prescribe these drugs for patients with migraine-mediated ED.

Sildenafil Can Trigger Cluster Headaches - Evans - 2006 - Headache: The ...

Phosphodiesterase-5 inhibitors commonly trigger migraines but rarely trigger cluster headaches. Two cases of cluster headaches triggered by sildenafil are described.