How does Viagra work? - Drugs.com

Viagra removes the block so things can proceed normally. Until the process begins, there is nothing for Viagra to do. TA. tark 7 July 2010. Simple notes how viagra work: Viagra Inhibits an enzyme called phosphodiesterase type 5 (PDE-5), making muscle in the penis more likely to relax and allowing blood to flow in, causing an erection.

Sildenafil: from angina to erectile dysfunction to pulmonary ... - Nature

Registration and marketing of Viagra for ED. By 1997 more than 4,500 subjects had been exposed to sildenafil, and 21 separate clinical trials had demonstrated the efficacy of sildenafil in various ...

Molecular mechanisms of the effects of sildenafil (VIAGRA)

The molecular mechanisms of the effects of sildenafil, a specific inhibitor of cyclic guanosine monophosphate (cGMP) phosphodiesterases are briefly reviewed. The second messenger cGMP as well as its molecular targets (with the exception of the photoreceptor signal transduction machinery) have long p …