Effect of sildenafil citrate on blood pressure and heart rate in men ...

Mean changes from baseline in heart rate for men taking antihypertensive medication were -0.6 beats/min after sildenafil and 0.9 beats/min after placebo compared with 0.4 beats/min and -0.6 beats/min, respectively, for patients not taking antihypertensive medication. Differences in SBP, DBP, and heart rate between the patients taking and those ...

The Effects of Sildenafil on Heart Rate Variability in

By contrast, Fogari and colleagues previously reported an increase in heart rate and a decrease in HRV after oral administration of 50 mg of sildenafil in a small-sized mixed gender study with healthy humans. 6 Piccirillo and co-workers described an increase in sympathetic outflow to heart and a decrease in cardiac vagal tone by means of HRV ...

Cardiovascular effects of sildenafil citrate and recommendations for ...

In addition, sildenafil does not appear to significantly affect heart rate.11,12. It has been postulated that the lack of major cardiovascular effects of sildenafil may be related to its preferential inhibition of PDE5, which is concentrated in male and female genitalia. ... Viagra (sildenafil citrate) package insert.Pfizer Inc, New York, 1998 ...