The potential toxic combination of grapefruit juice and sildenafil

In both the studies grapefruit led to an increase of peak concentration (Cmax) of sildenafil in plasma. One author showed that grapefruit juice increased the mean oral bioavailability of sildenafil by 23%. Concluding, the important growth in grapefruit juice consumption should be carefully considered by pharmacists and health professionals.

Don't mix Viagra and grapefruit, doctors say | wwltv.com

Don't mix Viagra and grapefruit, doctors say - You may remember a few weeks ago, doctors expanded the list of the number of medications that can have serious interactions with grapefruit or its juice.

Viagra and Grapefruit (Sildenafil) - Drugsdb.com

Preventing Grapefruit-Viagra Interactions. To prevent possible drug interactions and its complications, it is important to avoid grapefruit and grapefruit juice. It is also important to understand that grapefruit can stay in the body for up to 24 hours. This means that you should not take grapefruit even if you use Viagra only on as needed basis.

Sildenafil - Health Information Library - PeaceHealth

In one study, ingestion of 250 ml (approximately 1 cup) of grapefruit juice one hour before and together with sildenafil increased the total amount of sildenafil absorbed by 23%, but tended to delay the absorption of the drug. The authors of this study recommended that sildenafil and grapefruit juice not be taken together.

Grapefruit: MedlinePlus Supplements

Sildenafil (Viagra) Grapefruit can decrease how quickly the body breaks down sildenafil. Drinking grapefruit juice while taking sildenafil can increase the effects and side effects of sildenafil. ... Neuvonen PJ. Grapefruit juice can increase the plasma concentration of methylprednisolone. Eur J Clin Pharmacol 2000;56:489-93. View abstract ...