What Drugs Will Disqualify Drivers from Operating Commercial Vehicles?

The DOT Drug Test Panel. Drivers who are required to be enrolled in a DOT drug and alcohol testing program will be tested during the pre-employment process, and then periodically afterward, for the following substances:. Marijuana ; Cocaine ; Amphetamines (Amphetamine, Methamphetamine, MDMA, MDA) Opioids (Codeine, Morphine, Heroin, Hydrocodone, Hydromorphone, Oxycodone, Oxymorphone)

Frequently Asked Questions - Medications and DOT Physical Requirements

What if the DOT drug screen tests positive? The DOT drug screen is looking for illegal or non-prescription drugs. Yet, sometimes normal prescription medications can trip a positive test. If the urinalysis is positive for one or more of the drugs on the 5 panel drug test, then the driver will be contacted in person by the Medical Review Officer.