Would You Take Viagra for the Brain? - The WellMan

It works on multiple neurotransmitter systems in the brain; particularly boosting dopamine, neorepinephrine and histamine. Dopamine: No, not a backhanded nickname for your spouse; dopamine is a neurotransmitter associated with pleasurable reward. By triggering the dopamine system modafinil keeps you alert and awake.

Central action of sildenafil on arousal and reward pathways

Experimental evidence for sildenafil's action in the central nervous system: dopamine and serotonin changes in the medial preoptic area and nucleus accumbens during sexual arousal. J. Sex.

Modulation of Dopaminergic Pathways to Treat Erectile Dysfunction

Dopaminergic pathways involved in penile erection (drawn in black). Imagination, memory recall, olfactory, visual and tactile stimuli are processed in cortex and lead to increased dopamine levels in the paraventricular nucleus of hypothalamus followed by the activation of dopamine D 2, D 3, D 4 receptors and increase in neuronal nitric oxide synthase (nNOS) activity in oxytocinergic neurons ...

Erectile Function and Sexual Behavior: A Review of the Role of Nitric ...

These studies show that NO facilitates penile reflexes (e.g., penile erections induced by simulation of the genitalia) and dopamine release in the medial preoptic area of male rats by acting as a retrograde messenger to increase glutamic acid neurotransmission, which is responsible for the increase in dopamine release induced by copulation ...

The impact of phosphodiesterase-5 inhibitor (sildenafil citrate) on ...

Viagra [SC] is a forceful oral ... the principal neurotransmitter controlling vascular dilation, norepinephrine (NEP), dopamine (Dop), and gamma-aminobutyric acid (GABA) function together to SC sexual contributions ... SC had a marked increase in the number of entries of open arms than control animals (p < 0.001) when administered SC at a low ...