Tonic-clonic seizures in patients taking sildenafil - The BMJ

Sildenafil citrate (Viagra) is a specific phosphodiesterase type V inhibitor with a selective inhibitory effect on cyclic guanosine monophosphate (cGMP). Its enhancement of nitric oxide release leads to an increase in cGMP concentrations, which is responsible for its main clinical effect—relaxation of the smooth muscle in the corpus cavernosum. The increase in blood flow into the penis helps ...

Influence of sildenafil on the anticonvulsant action of selected ...

With respect to PTZ-induced seizures, it is interesting to note that sildenafil decreases seizure threshold when PTZ is administered intravenously (i.v.; timed infusion) (Riazi et al. 2006; Gholipour et al. 2009; Nieoczym et al. 2010b) and does not affect seizure threshold when PTZ is given s.c. (present study). This may point to marked ...

Severe hyponatremia associated with sildenafil (Viagra) - PMC

Four cases of epileptic seizures and one case of hyponatremia that were encountered during the clinical trials of sildenafil were reported to Pfizer, the manufacturer of the drug.