Sildenafil use and increased risk of incident melanoma in US men: a ...

Sildenafil citrate (Viagra) is a phosphodiesterase (PDE) 5A inhibitor commonly used for erectile dysfunction. Recent studies have shown that BRAF activation down-regulates PDE5A levels, and low PDE5A expression by BRAF activation or sildenafil use increases the invasiveness of melanoma cells, which raises the possible adverse effect of ...

Erectile Dysfunction Medicines Do Not Cause Melanoma, Analysis of Large ...

Use of the erectile dysfunction drug Viagra does not cause the development of melanoma, a deadly form of skin cancer.. This is the main finding of new research led by investigators at NYU Langone Medical Center and its Perlmutter Cancer Center and published online May 19 in the Journal of the National Cancer Institute.. While the researchers found an overall 11 percent increase in the risk of ...

Sildenafil Use and the Risk of Melanoma - Cancer Therapy Advisor

Sildenafil inhibits PDE 5A which causes increased levels of cyclic guanosine monophosphate ... it may be interesting to conduct studies evaluating the risk of melanoma with vardenafil and ...

Erectile dysfunction medicines do not cause melanoma ... - ScienceDaily

Use of the erectile dysfunction drug Viagra does not cause the development of melanoma, a deadly form of skin cancer, a new report concludes. Share: Facebook Twitter Pinterest LinkedIN Email

Viagra releases the brakes on melanoma growth - PMC

Use of the phosphodiesterase 5 (PDE5) blocker sildenafil (Viagra) has been linked to an increased risk of melanoma. In a recent study we discovered a growth-promoting cGMP pathway in melanoma cells. cGMP degradation via PDE5 acts as a brake on this pathway. ...

No Causal Link between Phosphodiesterase Type 5 Inhibition and Melanoma

INTRODUCTION. Ever since the introduction of sildenafil 20 years ago, phosphodiesterase type 5 (PDE5) inhibitors have become the mainstay therapy in the treatment of penile erectile dysfunction (ED), which can be severely limiting in an estimated 5% to 20% of men worldwide [].PDE5 inhibitors work by blocking the PDE5 enzymatic activity that degrades cyclic guanosine monophosphate (cGMP), a ...