Intracavernosal sildenafil facilitates penile erection independent of ...

In a separate protocol, sildenafil dose response determinations were performed in the presence of the guanylyl cyclase inhibitor, 1H-[1,2,4]-oxadiazolo-[4,3-a]-quinoxalin-1-one (ODQ; 3 microM) or vehicle (50% dimethyl sulfoxide [DMSO]). Relaxation to sildenafil in the presence of DMSO was significantly enhanced relative to sildenafil alone.

Sildenafil (Viagra) Prolongs Cardiac Repolarization by Blocking the ...

Experiments with isolated guinea pig hearts were performed as described previously. 5 The hearts were perfused with Krebs-Henseleit buffer during a control period of 10 minutes, followed by 15 minutes with buffer containing 30 μmol/L of sildenafil dissolved in 100 μL of dimethylsulfoxide (DMSO). Perfusion with buffer containing no drug was then restarted during a 10-minute washout period.

Sildenafil (VIAGRA - ScienceDirect

Sildenafil (VIAGRA TM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction. ... Inhibitors were dissolved in DMSO and concentration-response curves were constructed over the range 3×10 −10 to 1×10 −4 in half log increments.

Relaxant action of sildenafil citrate (Viagra) on human myometrium of ...

Sildenafil citrate was dissolved directly in dimethyl sulfoxide (DMSO) to obtain a 1-mol/L stock solution and diluted to the appropriate concentration in Krebs-Henseleit solution. The maximum DMSO content did not exceed 0.2%. The effects of vehicle (DMSO) were tested by the preparation of test solutions with Krebs-Henseleit in place of sildenafil.

Dimethyl Sulfoxide (DMSO) and Heart Disease - drsircus.com

Dimethyl sulfoxide (DMSO) is one of the safest medically active substances in existence and has been investigated for its potential effects on arterial plaque and atherosclerosis. Discovered in 1866, Russian scientist Alexander Saytzeff isolated DMSO. It was crystalline, odorless, non-toxic, and tasted like garlic when consumed.