The start of pharmacological activity after sublingual administration ...

For the first 3 months patients were asked to take Sildenafil (50-100 mg) for oral administration, under normal everyday conditions, 30 minutes before planned sexual relations. During the second 3 months the patients were asked to take Sildenafil for sublingual administration (crushing the pill in the mouth and dissolving the drug under the ...

Rapid-Onset Sildenafil Sublingual Drug Delivery Systems:

The result was that the time it took for the drug to be effective was basically cut in half: 62.8 min for Viagra swallowed whole vs. 29.3 min for crushed Viagra placed under the tongue. 16 All patients declared that they preferred the sublingual way because of its faster onset. Almost all studies of sildenafil in drug delivery systems were ...

Journal of Pharmaceutical Sciences

comparison of 6 men taking Viagra as intended (swallowed whole) for 3 months, followed by 3 months of taking Viagra that had been crushed into a powder and placed in the mouth under the tongue. The result was that the time it took for the drug to be effective was basically cut in half: 62.8 min for Viagra swallowed whole vs. 29.3

Frontiers | Sublingual Administration of Sildenafil Oro-dispersible ...

For ODT and ODF, patients were instructed to hold the formulation under the tongue for 15 min without the assumption of water, followed by swallowing. Venous blood samples were collected in standard tubes (Vacutainer, BD Biosciences, Milan, Italy) at 0, 5, 10, 15, 30, 60, 90, 120, and 240 min after drug administration.