A Controlled Trial of Sildenafil in Advanced Idiopathic Pulmonary ...

Sildenafil (Revatio, Pfizer) is a phosphodiesterase-5 inhibitor that stabilizes the second messenger of nitric oxide, cyclic guanosine monophosphate, which leads to pulmonary vasodilatation.

Update on the clinical utility of sildenafil in the treatment of ...

Additional studies of patients with heart failure and pulmonary hypertension demonstrated that sildenafil treatment was associated with improved ventilator efficiency, as determined by Ve/VCO 2 slope by cardiopulmonary stress testing, and correlated with drops in pulmonary vascular resistance and improvement in RV ejection fraction.64 ...

Sildenafil for chronic obstructive pulmonary disease: a ... - PubMed

Rationale: Pulmonary hypertension with exercise is common in chronic obstructive pulmonary disease (COPD) and may contribute to exercise limitation in this disease. We aimed to determine the effects of treatment with sildenafil on exercise capacity in patients with COPD and emphysema. Methods: We performed a randomized, double-blind, placebo-controlled 2-period crossover trial of sildenafil ...

Randomized, Multicenter Study to Assess the Effects of Different Doses ...

Pulmonary arterial hypertension (PAH) is a subtype of pulmonary hypertension, characterized by pulmonary arterial remodeling. This life-threatening disease, if untreated, rapidly progresses to right heart failure and death. 1-3 Sildenafil citrate, an orally active, selective phosphodiesterase-5 inhibitor is approved for the treatment of PAH in adults and children. 4-6 The pivotal SUPER-1 ...

Does sildenafil also improve breathing? - PubMed

Sildenafil is being used by a number of patients with erectile dysfunction. Some of these patients also may have concomitant COPD. The effect of sildenafil on lung function is not known. Two patients with severe COPD and erectile dysfunction reported that their dyspnea improved when they took oral s …