Comparison of the Erectile Dysfunction Drugs Sildenafil and Tadalafil ...

Thus, it is likely that the lingering action of tadalafil could have aggravated the pain associated with PDE5 action . Expectedly, patients who mentioned serious medication safety as the primary topic gave the lowest drug rating (2.44) compared with those who mentioned medication safety (3.30) or mild medication safety (3.52) as the primary topic.

PDE5 Inhibitors - StatPearls - NCBI Bookshelf

The discovery of phosphodiesterase 5 inhibitors (PDE5 inhibitors) for causing the erection of the penis was accidental, noticed as a side effect while being administered to investigate their ability to treat hypertension and angina. Phosphodiesterase 5 Inhibitors (PDE5Is) are now widely used in the management of erectile dysfunction. This activity illustrates the indications, mechanism of ...

Tadalafil in the treatment of erectile dysfunction; an overview of the ...

Across all patients on tadalafil 10 mg and 20 mg, 71% and 84% reported improved erection (GAQ) versus 33% in the placebo group. The total number of successful attempts, as a proportion of the total number of attempts made, was 61% and 72% respectively, compared with 34% of placebo (p<0.001).