Nitroglycerin with Sildenafil Interaction Details - HelloPharmacist

Male patients with stable angina (n=20) and healthy male subjects (n=33) were challenged with a single sublingual nitroglycerin 400 mcg spray at 1 hour, 4 hours, 6 hours, and 8 hours after administration of a sildenafil 100 mg oral tablet to determine the time course of the hypotensive interaction between sildenafil and sublingual nitroglycerin.

How does Nitroglycerin Interact with Type 5 Phosphodiesterase ...

Nitrates and type 5 phosphodiesterase inhibitors (i.e., avanafil (Stendra), sildenafil (Viagra); tadalafil (Cialis); vardenafil (Levitra) can both cause vasodilation of blood vessels. PDE5 inhibitors interact with nitrates by decreasing the metabolism of nitric oxide induced activation of cGMP, thereby allowing more cGMP mediated smooth muscle ...