Methylphenidate - Wikipedia

Methylphenidate, sold under the brand names Ritalin (/ ˈ r ɪ t ə l ɪ n / RIT-ə-lin) and Concerta (/ k ə n ˈ s ɜːr t ə / kən-SUR-tə) among others, is a central nervous system (CNS) stimulant used medically to treat attention deficit hyperactivity disorder (ADHD) and, to a lesser extent, narcolepsy.It is a first-line treatment for ADHD (e.g. in the UK [16]); it may be taken by mouth ...

Effects of methylphenidate and MDMA on appraisal of erotic ... - PubMed

Whether methylphenidate or MDMA alter sexual arousal or cognitive appraisal of intimate relationships is not known. Thus, we evaluated effects of methylphenidate (40 mg) and MDMA (75 mg) on subjective sexual arousal by viewing erotic pictures and on perception of romantic relationships of unknown couples in a double-blind, randomized, placebo-controlled, crossover study in 30 healthy adults.

The Pharmacology of Amphetamine and Methylphenidate: Relevance to the ...

Preclinical studies Amphetamine al-Tikriti et al ()• AMP increased the washout rate of [123 I]IBF (a D 2 receptor antagonist) from the striatum of baboons, as measured using SPECT Annamalai et al ()• AMP-stimulated downregulation of the NET was linked to the PKC-resistant T258/S259 structural motif and mediated by reduced plasma membrane insertion and enhanced endocytosis

Methylphenidate hydrochloride | Drugs | BNF | NICE

For methylphenidate hydrochloride. Initially 5 mg 1-2 times a day, increased in steps of 5-10 mg daily if required, at weekly intervals, increased if necessary up to 60 mg daily in 2-3 divided doses, increased if necessary up to 2.1 mg/kg daily in 2-3 divided doses, the licensed maximum dose is 60 mg daily in 2-3 doses, higher dose ...

Methylphenidate: 7 things you should know - Drugs.com

Methylphenidate is composed of 2 enantiomers (optical isomers): d-threo and l-threo. The d-threo enantiomer is more pharmacologically active than the l-threo enantiomer and is available commercially as dexmethylphenidate. Methylphenidate belongs to the group of medicines known as central nervous system (CNS) stimulants. 2. Upsides

Attention deficit hyperactivity disorder: Methylphenidate - CKS | NICE

Methylphenidate can impair cognitive function and affect the person's ability to drive. People taking methylphenidate should be told that this medicine may affect their ability to drive and they should not drive if they are affected. Dermatological effects such as pruritus and rash. Other adverse effects, including reduced weight gain, cough ...

Methylphenidate: a medicine used to treat attention deficit ... - NHS

Methylphenidate is used to treat attention deficit hyperactivity disorder (ADHD). It is also sometimes used to treat narcolepsy. It comes as standard (immediate release) tablets and capsules. You can also get slow release (extended, modified or prolonged release) tablets and capsules which release the medicine into your body gradually.

Methylphenidate - an overview | ScienceDirect Topics

Methylphenidate is a dopamine agonist approved for the treatment of attention deficit hyperactivity disorder. Methylphenidate is a dopamine and noradrenaline reuptake inhibitor and primarily blocks reuptake of monoamines into the synapse, thereby increasing concentrations of monoamines at the synaptic cleft (Karila et al., 2010).