Sildenafil - LiverTox - NCBI Bookshelf

Sildenafil functions as a selective and competitive inhibitor of type 5 phosphodiesterases (PDE5) on smooth muscle cells in the penis and pulmonary vasculature, and is used extensively for erectile dysfunction and less commonly for pulmonary hypertension. Sildenafil has been associated with rare instances of clinically apparent liver injury.

Effect of sildenafil citrate on the liver structure and function in ...

The study conducted by Nna et al. reports that as it is indicated in the increased serum concentration of liver enzymes and bilirubin, significant alteration in liver functions could occur following the chronic administration of sildenafil in adult Wistar rats; and only a poor reversal of hepatotoxicity was observed after the withdrawal of the ...

14 Medications That May Raise Your Risk of Liver Damage - GoodRx

Many people take nonsteroidal anti-inflammatory drugs to help relieve pain, inflammation, and fever.Some are available OTC, but others — like oral diclofenac (Cataflam) — are available by prescription only.. Diclofenac is one of the most likely NSAIDs to cause liver injury. In many cases, the damage is significant enough to cause elevated liver function tests (LFTs) but not enough to cause ...

Effect of Sildenafil on Non-Alcoholic Fatty Liver - Science Alert

The NAFLD may be detected via routine laboratory tests showing elevated liver enzymes or when an ultrasound is performed for various reasons and detects liver ... mental illness and use of drugs or alcohol abuse, was excluded from the study. Endocrine causes of ED were also excluded. Similarly, those patients who had contraindications to PDE5 ...

PDF Sildenafil-associated hepatoxicity: a review of the literature

hepatic cirrhosis, elevated hepatic pressure) can affect sildenafil clearance leading to an increased drug concentration inside the body12. Liver tox-icity related to sildenafil consumption has been considered a very rare event. However, in the last 10 years, some cases of sildenafil-associated hepatotoxicity have been reported13-18. It is well

Sildenafil-associated hepatoxicity: a review of the literature

Sildenafil citrate (Viagra®) is a vasoactive agent available worldwide since 1998 for the treatment of male erectile dysfunction. It is a selective phosphodiesterase type 5-enzyme inhibitor able to potentiate the downstream effects of nitric oxide on smooth muscle relaxation and vasodilation through its effects on the cyclic guanosine monophosphate (c-GMP) pathway in the erectile tissue of ...

Elevated liver enzymes Causes - Mayo Clinic

Many diseases, medications and conditions can cause elevated liver enzymes. Your healthcare team will review your medicines and symptoms and sometimes prescribe other tests and procedures to find the cause. Common causes of elevated liver enzymes include: Nonprescription pain medicines, particularly acetaminophen (Tylenol, others).