Sildenafil | C22H30N6O4S | CID 135398744 - PubChem

Sildenafil is a phosphodiesterase-5 (PDE5) inhibitor that is predominantly employed for two primary indications: (1) the treatment of erectile dysfunction; and (2) treatment of pulmonary hypertension, where: a) the US FDA specifically indicates sildenafil for the treatment of pulmonary arterial hypertension (PAH) (WHO Group I) in adults to improve exercise ability and delay clinical worsening.

Practice Exam 1 key - Oregon State University

Sildenafil is sold under the trade name Viagra and is approved for the treatment of impotence. Complete the following tasks on the structure of Viagra. Add all the lone pairs implied in this structure. ... ** note that one of the lone pairs on oxygen is conjugated to the pi bond for resonance** 4) Rank the following in order of increasing pKa: ...

Structural Biochemistry/Viagra (Sildenafil Citrate) - Wikibooks

In 1998, the drug Viagra was introduce as an effective way to treat male erectile dysfunction (MED). It goes by the generic name of sildenafil citrate. It has quickly become one of the most popular and most prescribed drugs in the world. Its annual sales account for over a billion dollars each year. Sildenafil was synthesized by a group of ...

How to Determine the Number of Lone Pairs - Chemistry Steps

A negatively charged carbon atom should immediately tell you about a lone pair of electrons. In this case, since the carbon has only three bonds and a negative charge, it must also have a lone pair. This can also be confirmed by using the formula: FC= V - (N + B) -1 = 4 - (N + 3) N = 2, thus, one lone pair of electrons

(PDF) Sildenafil (ViagraTM): Synthesis Step by Step and its ...

rich (п-excessive) and the lone pair of the heteroatom is part of the . ... (Viagra) is 50 mg once per day approximately 60 minutes before sexual . activity with the lasting e ects up to 4 hours ...

Solved How many Carbon atoms: How many Hydrogen atoms: How - Chegg

Question: How many Carbon atoms: How many Hydrogen atoms: How many Oxygen atoms: How many Nitrogen atoms: Viagra How many Sulfur atoms: 5-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-1-methyl-3-propyl-1,6-dihydro- 7H-pyrazolo[4,3-d]pyrimidin-7-one How many Lone Pairs (unpaired electrons): What is formal charge:

Solved Consider the nitrogen atoms (labeled A-F) in the - Chegg

Question: Consider the nitrogen atoms (labeled A-F) in the molecule of Viagra shown below. Which of these nitrogen atoms possesses a delocalized lone pair of electrons? v layıa Nitrogen A Nitrogen B Nitrogen C Nitrogen D Nitrogen E Nitrogen F None of the indicated lone pairs are delocalized All of the indicated lone pairs are delocalized Nitrogens A and F Nitrogens B,

Solved How many lone pairs are present in the chemical | Chegg.com

How many lone pairs are present in the chemical structure of Viagra? What is the formal charge? Can you explain the difference? There are 2 steps to solve this one. Who are the experts? Experts have been vetted by Chegg as specialists in this subject. Expert-verified. Step 1.

An Overview of the Synthetic Routes to Sildenafil and Its Analogues

Sildenafil (Viagra), a known selective and potent inhibitor of PDE5, was the first drug for . ... and oxygen lone pair of the alkoxy group maintaining coplanarity between the phenyl and .